Background and Objectives: Many herbal preparations have been recommended in alternative system of medicine for the treatment of hepatic disorder. Drug-induced hepatotoxicity is still a significant unresolved clinical problem as liver is the most common site of damage. It is well known that overdoses of acetatminophen are hepatotoxic. The goal of the present work is to evaluate and compare the efficacy of root extract of Polygonumbistorta and tannic acid against toxicant induced damage in liver and kidney.
Methods: Male rats (150±10g b.w.) were administered a single bolus dose of acetaminophen (2 g/kg, p.o.). Plant extract (PB) and its active principle (TA) was given at the dose of 100 mg/kg and 25 mg/kg, respectively (p.o.) after 24 h of toxicant administration.
Results: The hepatotoxicity produced by acute paracetamol administration was found to be inhibited by Polygonumbistorta and tannic acid with evidence of decreased levels of serum transaminases, alkaline phosphatase, protein, albumin, bilirubin, urea, creatinine, triglycerides and cholesterol concentration whereas increase was found in blood sugar. A significant rise was observed in lipid peroxidation level however reduced glutathione content was decreased. A concomitant fall was observed in the enzymatic activities of adenosine triphosphatase, glucose-6-phosphatase and histopathological findings. Plant extract and its active principle prevent the development of acute liver damage, thus supported these biochemical and histopathological findings.
Conclusion: The results of this study clearly indicate that PB and TA have a potent hepatoprotective action; whereas tannic acid is showed protective effect compare to Polygonumbistorta against Acetaminophen-induced toxicological profile.
Article info
Identification
Copyright
© 2013 Published by Elsevier Inc.
